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Picosecond Laser-Induced Photothermal Skin Damage Evaluation by Computational Clinical Trial
Y Shimojo1, T Nishimura1, H Hazama1
1Graduate School of Engineering, Osaka University, Suita, Japan.
Laser Therapy
|September 9, 2020
Summary
Computational clinical trials (CCTs) offer a novel method for evaluating laser medicine safety. This study demonstrates CCT feasibility for a picosecond laser, showing significantly less thermal damage compared to approved devices.
Area of Science:
- Biomedical Engineering
- Laser Medicine
- Computational Modeling
Background:
- Computational clinical trials (CCTs) leverage numerical modeling for laser medicine.
- Simulating laser-tissue interactions aids in novel device application.
- Evaluating the safety of new laser devices is crucial for clinical adoption.
Purpose of the Study:
- To confirm the feasibility of CCT for skin treatment with a novel picosecond laser.
- To present a computational method for evaluating laser device safety.
- To assess the safety of a new picosecond laser device.
Main Methods:
- Numerical modeling of light propagation and thermal diffusion in a skin model.
- Simulation of ultrashort laser pulse irradiation effects.
- Safety evaluation based on photothermal damage calculations and comparison with approved lasers.
Main Results:
- Picosecond laser irradiation induced minimal epidermal thermal damage (1.2 × 10^-2%).
- Simulated thermal damage was significantly lower than that of approved laser devices.
- Computational safety predictions aligned with existing clinical trial data.
Conclusions:
- CCT is a feasible approach for evaluating novel medical laser device safety.
- This computational method provides a rapid and appropriate way to predict and assess laser device safety.
- CCT offers an alternative to traditional preclinical and clinical testing for laser devices.
