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Recent advances in topical carriers of anti-fungal agents

Abhinava Garg1, Ganti S Sharma1, Amit K Goyal2

  • 1Department of Pharmaceutics, I.S.F.College of Pharmacy, Moga, Punjab, India.

Heliyon
|September 9, 2020
PubMed

Insights

Advanced topical nanocarriers improve antifungal drug delivery for skin infections, offering enhanced therapeutic response and reduced toxicity compared to conventional methods.

Area of Science:

  • Dermatology and Pharmaceutical Sciences
  • Nanotechnology in Drug Delivery

Background:

  • Fungal skin infections are a prevalent global health concern.
  • Topical antifungal therapy is preferred for its targeted action and reduced side effects.
  • Conventional topical delivery systems face challenges like poor retention and low bioavailability.

Purpose of the Study:

  • To review recent advancements in novel topical carriers for antifungal drugs.
  • To highlight strategies for improving the therapeutic performance of antifungal medications.
  • To discuss the advantages of nanocarriers in topical antifungal therapy.

Main Methods:

  • Literature review of recent scientific evidence.
  • Analysis of advanced topical carrier systems for antifungal agents.
  • Summary of nanocarrier types used in topical antifungal medication.

Main Results:

  • Topical nanocarriers loaded with antifungal agents show superior therapeutic outcomes.
  • Nanocarriers effectively overcome biopharmaceutical challenges of conventional delivery.
  • Various nanocarrier systems like nanoparticles, microemulsions, and liposomes demonstrate efficacy.

Conclusions:

  • Novel topical nanocarriers represent a significant advancement in treating fungal skin infections.
  • These advanced systems offer enhanced bioavailability and targeted drug delivery.
  • The use of nanocarriers minimizes toxicity and improves patient outcomes for antifungal therapy.
Keywords:
Infectious diseaseLiposomesMaterials applicationMaterials scienceMicrobiologyMicroneedleMicrosponge gelNanogelNanomaterialsNiosomesPharmaceutical scienceSolid-lipid nanoparticles

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