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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Introduction
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Exercise and Cardiovascular Response01:20

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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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Related Experiment Video

Updated: Dec 9, 2025

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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Type 2 Inflammatory Biomarker Response After Exercise Challenge Testing.

Ellen Tufvesson1, Henning Stenberg1, Jaro Ankerst1

  • 1Respiratory Medicine and Allergology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Journal of Asthma and Allergy
|September 9, 2020
PubMed
Summary
This summary is machine-generated.

Exercise increases interleukin-13 (IL-13) in both asthmatic and healthy individuals, suggesting a physiological response. Levels of thymus and activation-related chemokine (TARC) and leukotrienes were also altered post-exercise.

Keywords:
asthmabiomarkersexerciseinflammation

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Area of Science:

  • Exercise physiology
  • Immunology
  • Respiratory medicine

Background:

  • Exercise-induced bronchoconstriction (EIB) is linked to airway osmotic stress and inflammatory mediator release.
  • Several type 2 (T2) mediators are implicated in EIB, but the overall T2 response during exercise remains unclear.

Purpose of the Study:

  • To investigate T2 biomarkers in plasma and urine before and after exercise challenge in asthma patients and healthy controls.
  • To determine if exercise elicits a T2 inflammatory response in individuals with and without asthma.

Main Methods:

  • 22 mild asthma patients and 18 healthy controls underwent a treadmill exercise challenge.
  • Plasma and urine samples were collected pre- and post-exercise (up to 60 min).
  • Interleukin-13 (IL-13), thymus and activation-related chemokine (TARC), periostin, and leukotrienes were measured.

Main Results:

  • Plasma IL-13 increased significantly in all subjects post-exercise, peaking at 10 minutes.
  • Plasma TARC increased in controls but not in asthmatics; plasma Cys-LT decreased in all subjects.
  • Urine IL-13 and leukotriene E4 (LTE4) increased post-exercise, with LTE4 more pronounced in asthmatics.

Conclusions:

  • Exercise induces a similar increase in circulating IL-13 in both asthmatics and controls, indicating a physiological response.
  • Exercise also affects TARC and leukotriene levels, suggesting a broader inflammatory mediator involvement.