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In Vitro Analysis of E3 Ubiquitin Ligase Function
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MDM2-C Functions as an E3 Ubiquitin Ligase.

Jun Yeob Kim1, Rusia Lee1,2, Gu Xiao1

  • 1The Department of Biological Sciences, Hunter College, City University of New York, New York, NY, USA.

Cancer Management and Research
|September 9, 2020
PubMed
Summary

The MDM2-C protein isoform exhibits E3 ubiquitin ligase activity, promoting ubiquitination of both wild-type and mutant p53. This finding clarifies MDM2-C

Keywords:
MDM2 splice variantsbreast cancermutant p53wild-type p53

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