Gaps or links between hormonal therapy and schizophrenia? (Review).
Simona Corina Trifu1, Diana Istrate2, Drăgoi Ana Miruna3
1Department of Clinical Neurosciences, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Experimental and Therapeutic Medicine
|September 9, 2020
Summary
Estrogen
Area of Science:
- Neuroendocrinology
- Psychiatry
- Hormone research
Background:
- Schizophrenia is a severe psychiatric disorder with observable brain abnormalities.
- Hormonal fluctuations, particularly in women, are linked to mental health changes.
- Differences exist in schizophrenia presentation and progression between males and females.
Purpose of the Study:
- To review the role of estrogen in schizophrenia.
- To explore hormonal therapy's potential in improving schizophrenia outcomes.
Main Methods:
- Review of existing literature on schizophrenia, endocrinology, and hormonal influences.
- Analysis of clinical trials investigating hormonal therapies in schizophrenia patients.
Main Results:
- Hormonal therapies, like those for breast cancer and osteoporosis, may improve schizophrenia outcomes.
- Estrogen's impact on brain development and schizophrenia evolution is significant.
Conclusions:
- Hormonal therapy presents a promising avenue for improving schizophrenia treatment.
- Understanding hormone's role in brain development is key to novel schizophrenia therapies.
Related Concept Videos
01:29Biological Causes of Schizophrenia
352
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
352
01:29Psychological and Sociocultural Causes of Schizophrenia
356
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
356
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.6K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.6K
01:28Drug Therapy
185
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
185
01:22Target Cell Response to Hormones
4.8K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
4.8K
01:28Psychosis and Antipsychotic Drugs: Overview
670
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
670