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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Multiple sclerosis, human herpesvirus 4 and thyroid collision tumor: A case report.

Anca Maria Sirbu¹, Carmen Adella Sirbu^2,3, Lucian Eftimie^4,5,6

¹Department of Endocrinology, 'C.I. Parhon' National Institute of Endocrinology, 011863 Bucharest, Romania.

Experimental and Therapeutic Medicine

|September 9, 2020

Summary

This case study reports the first known association between multiple sclerosis (MS) and simultaneous thyroid collision tumors in a patient treated with interferon beta-1b (IFNβ-1b). Epstein-Barr virus (EBV) may be a contributing factor.

Keywords:

calcitonin disease-modifying therapy human herpesvirus 4 immunohistochemistry interferon β-1b medullary thyroid carcinoma multiple sclerosis papillary thyroid cancer thyroglobulin thyroid collision tumors

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Area of Science:

Neuroimmunology
Endocrinology
Oncology

Background:

The role of interferon beta-1b (IFNβ-1b) in cancer development, particularly in multiple sclerosis (MS) patients, remains unclear.
Human herpesvirus 4 (Epstein-Barr virus, EBV) has been implicated in both MS and thyroid cancer.
Simultaneous occurrence of different thyroid cancer types (collision tumors) is rare, especially in conjunction with MS.

Purpose of the Study:

To report a rare case of simultaneous papillary and medullary thyroid carcinomas in a young woman with a history of multiple sclerosis.
To investigate potential contributing factors, such as EBV and prior MS therapy, in the development of these co-occurring conditions.

Main Methods:

Case report of a 46-year-old female diagnosed with relapsing-remitting MS.
Diagnostic workup included cervical MRI, thyroid function tests, calcitonin level measurement, and EBV serology.
Surgical intervention involved total thyroidectomy and cervical lymph node dissection, followed by radioactive iodine therapy.

Main Results:

The patient presented with a thyroid nodule and elevated calcitonin levels, alongside positive EBV serology.
Histological examination confirmed concurrent papillary and medullary thyroid cancers (collision tumors).
Post-surgery, calcitonin levels normalized, and IFNβ-1b therapy was discontinued.

Conclusions:

This is the first reported case linking MS with thyroid collision tumors.
Immune-mediated inflammation associated with MS may contribute to the development of thyroid cancer.
EBV is considered a potential contributory factor, warranting further research into its role in simultaneous immune-related pathologies.