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Venous Thrombosis I: Introduction

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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

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Updated: Dec 9, 2025

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Risk factors for venous thromboembolism in endometrial cancer.

S Pin^1,2, J Mateshaytis¹, S Ghosh²

¹Obstetrics and Gynecology, University of Alberta, Edmonton.

Current Oncology (Toronto, Ont.)

|September 9, 2020

Summary

Venous thromboembolism (VTE) significantly increases mortality risk in endometrial cancer patients. Identifying high-risk factors like non-endometrioid histology and advanced stage is crucial for early intervention and improved survival outcomes.

Keywords:

Venous thromboembolism dvt endometrial cancer pe post-operative pulmonary embolism risk factors surgery vte

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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Area of Science:

Gynecologic Oncology
Hematology
Oncology

Background:

Venous thromboembolism (VTE) is a serious complication in cancer patients, particularly those with endometrial cancer, leading to poorer prognoses.
Understanding VTE incidence and risk factors in endometrial cancer is vital for improving patient outcomes.
Previous studies highlight the association between malignancy and adverse VTE events.

Purpose of the Study:

To determine the incidence of VTE in patients with endometrial cancer.
To identify specific risk factors contributing to VTE development in this patient population.
To compare survival rates between endometrial cancer patients with and without VTE.

Main Methods:

Retrospective chart review of 422 endometrial cancer patients who underwent surgery between January 2014 and July 2016.
Binary logistic regression and multivariate analysis were used to identify VTE risk factors.
Kaplan-Meier estimates and Cox proportional hazards models were employed to compare survival outcomes.

Main Results:

The overall VTE incidence was 6.16%, with 0.7% occurring within 60 days post-surgery.
Significant risk factors for VTE included non-endometrioid histology, stages 3-4 disease, laparotomy, and patient age.
Patients with VTE had a significantly higher overall death rate (42% vs. 9%), with a multivariable hazard ratio of 2.20 for death.

Conclusions:

Identifying endometrial cancer patients at high risk for VTE is critical due to its significant impact on survival.
The identified risk factors (non-endometrioid histology, advanced stage, laparotomy, age) can aid in recognizing high-risk individuals.
Early recognition and management of VTE in endometrial cancer patients may improve overall survival.