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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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An Intriguing Presentation of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

Syed P Quadri1, Nitesh K Jain2, Brooke L Brandon1

  • 1Medicine, Aurora Medical Center, Kenosha, USA.

Cureus
|September 9, 2020
PubMed

Hemophagocytic lymphohistiocytosis (HLH) is an immune related clinical syndrome with protean manifestations, varying presentation, clinically complex, with diverse causes, and is an under-recognized entity which carries high morbidity and mortality. It is precipitated by an immunological trigger in a susceptible host resulting in immune activation and dysregulation leading to disruption of immune homeostasis, cytokine storm and multi-organ failure. We describe a case of Epstein-Barr virus (EBV) associated HLH with its typical diagnostic challenges and associated high mortality rate. Certain diagnostic criteria and online tools may help to arrive at an earlier presumptive diagnosis which, in turn, may expedite treatment and lead to better clinical outcomes.

Keywords:
covid 19cytokine storm syndromeebvh scorehemophagocytic lymphohistiocytosis (hlh)high ferritinpancytopeniasecondary hemophagocytic lymphohistiocytosissecondary hlh

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