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The adaptor protein CARD9, from fungal immunity to tumorigenesis

Ying Wang1, Di Zhang1, Yayi Hou1,2

  • 1The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School of Nanjing University Nanjing 210093, China.

American Journal of Cancer Research
|September 9, 2020
PubMed

Insights

The CARD9 protein is crucial for innate immunity, regulating responses to fungal and bacterial infections. It also impacts adaptive immunity and plays a key role in colon cancer development and antitumor immunity.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cancer Research

Background:

  • The adaptor protein CARD9 mediates signals from pattern recognition receptors (PRRs) in myeloid cells to the transcription factor NF-κB.
  • CARD9 is essential for innate immunity, with deficiencies leading to increased susceptibility to fungal and bacterial infections in both mice and humans.
  • CARD9 signaling influences both the activation and shaping of adaptive immune responses.

Purpose of the Study:

  • To review the upstream and downstream signaling pathways of CARD9.
  • To summarize CARD9-induced immunological recognition and responses.
  • To examine the multifaceted roles of CARD9 in host immunity, including fungal immunity and tumorigenesis.

Main Methods:

  • Literature review of CARD9 signaling pathways.
  • Analysis of CARD9's role in innate and adaptive immunity.
  • Examination of CARD9's involvement in host defense and cancer development.

Main Results:

  • CARD9 signaling is pivotal for effective immune responses against pathogens.
  • CARD9 influences adaptive immunity, shaping immune cell functions.
  • CARD9 is implicated in colon cancer development and acts as a regulator of antitumor immunity.

Conclusions:

  • CARD9 is a critical adaptor protein with broad implications in host defense and cancer immunity.
  • Understanding CARD9 signaling pathways offers insights into treating infectious diseases and cancer.
  • Further research into CARD9's functions can elucidate novel therapeutic strategies.

Keywords:
CARD9CARD9-associated diseasesNF-κBimmunological recognitiontumorigenesis

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