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Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Dietary restriction and/or exercise training impairs spermatogenesis in normal rats.

Yinlam Li1,2, Li Zhang3, Xiaoguo Zheng1,2

  • 1International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme
|September 9, 2020
PubMed
Summary

Dietary restriction and exercise training can harm male reproductive health by reducing sperm count and motility. These interventions disrupt gene expression in the testes, potentially leading to reproductive dysfunction.

Keywords:
diet restrictionentraînement physiqueexercise traininggene ontologyontologie des gènesratrestriction alimentairespermatogenesisspermatogenèsetesticuletestis

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Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Exercise Physiology

Background:

  • Dietary restriction (DR) and exercise training (ET) offer health benefits but their impact on male reproductive function is not fully understood.
  • Mechanisms regulating reproductive function under DR and ET require further investigation.

Purpose of the Study:

  • To investigate the effects of DR and ET on spermatogenesis and sperm function in rats.
  • To elucidate the molecular mechanisms underlying these effects.

Main Methods:

  • Rats were assigned to four groups: ad libitum-fed control, DR, ET, and combined DR+ET.
  • Evaluated body weight, epididymal fat pad weight, sperm count, motility, and capacitation-associated protein tyrosine phosphorylation.
  • Utilized microarray analysis and gene ontology analysis to assess gene expression changes in the testes.

Main Results:

  • DR, ET, and DR+ET groups showed reduced body weight, epididymal fat pad weight, and sperm counts.
  • Sperm motility and capacitation-associated protein tyrosine phosphorylation were impaired in DR and DR+ET groups, but not ET alone.
  • Microarray analysis revealed more downregulated than upregulated genes, with significant overlap between DR and ET groups.
  • Gene ontology analysis identified overlapping pathways (e.g., glucocorticoid, corticosteroid, estradiol responses) affected by DR and/or ET.

Conclusions:

  • DR and/or ET can negatively impact male reproductive health by disrupting testicular gene expression.
  • Sperm function is more sensitive to DR than ET.
  • Both interventions impair spermatogenesis through shared biological pathways, suggesting potential risks for male reproductive dysfunction.