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Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

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Updated: Dec 9, 2025

Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
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Dual-specificity phosphatases in mental and neurological disorders.

Ning An1, Katherine Bassil1, Ghazi I Al Jowf2

  • 1Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; European Graduate School of Neuroscience, Maastricht University, Maastricht, the Netherlands.

Progress in Neurobiology
|September 9, 2020
PubMed
Summary

Dual-specificity phosphatases (DUSP) regulate neural functions and are linked to mental and neurological disorders like depression and Alzheimer's disease. This review explores DUSP genes in these conditions and future research directions.

Keywords:
DUSPMental healthNeurological diseasesPhosphatasePsychiatric disorders

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Dual-specificity phosphatases (DUSP) are key regulators of cellular signaling pathways.
  • These enzymes dephosphorylate tyrosine and serine/threonine residues, impacting diverse cellular processes.
  • Dysregulation of DUSP family members has been implicated in various neurological and psychiatric conditions.

Purpose of the Study:

  • To provide a comprehensive review of the DUSP gene family in the context of mental and neurological disorders.
  • To outline the structure and general functions of DUSP genes.
  • To summarize current literature and offer perspectives for future research.

Main Methods:

  • Literature review of studies on DUSP genes and their association with mental and neurological disorders.
  • Analysis of DUSP gene functions in neural processes such as neurogenesis, differentiation, and apoptosis.
  • Inclusion of data from various model systems.

Main Results:

  • DUSP genes play critical roles in modulating essential neural functions.
  • Specific DUSP family members are linked to the pathophysiology of depression and Alzheimer's disease.
  • Evidence from model systems supports the involvement of DUSP in neurological and mental health.

Conclusions:

  • The DUSP family represents a significant area of research for understanding and potentially treating mental and neurological disorders.
  • Further investigation into DUSP gene functions and their specific roles in disease is warranted.
  • Targeting DUSP pathways may offer novel therapeutic strategies for neurological and psychiatric conditions.