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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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Prenatal exposure to bisphenol - A is associated with dysregulated perinatal innate cytokine response and elevated

Sui-Ling Liao1, Li-Chen Chen2, Ming-Han Tsai1

  • 1Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Environmental Research
|September 9, 2020
PubMed

Insights

Prenatal bisphenol-A (BPA) exposure did not increase childhood allergy risk or impair infant lung function. However, BPA altered early immune biomarkers, suggesting a potential role in allergy development that warrants further investigation.

Area of Science:

  • Environmental Health
  • Immunology
  • Pediatrics

Background:

  • Conflicting reports exist on the link between prenatal bisphenol-A (BPA) exposure and childhood allergy development.
  • This study investigates BPA's impact on objective allergy markers, including cytokine profiles, atopic sensitization, and infant lung function (ILF).

Purpose of the Study:

  • To determine the association between prenatal BPA exposure and objective outcomes related to childhood allergy.
  • To assess BPA's impact on immune biomarkers and infant lung function.
  • To evaluate the relationship between prenatal BPA exposure and clinical allergic symptoms.

Main Methods:

  • A cohort of 274 children with cord BPA data was followed until age 3.
  • Assessed IgE levels and Toll-like receptor (TLR) stimulated cytokine production annually.
  • Measured ILF and determined allergic outcomes via questionnaires and physician assessments.

Main Results:

  • Prenatal BPA exposure showed a significant association with cord blood IgE levels and altered perinatal cytokine production (TNF-α, IL-6).
  • These associations were not sustained beyond birth.
  • No correlation was found between prenatal BPA concentration and ILF measurements or childhood allergic symptoms.

Conclusions:

  • Prenatal BPA exposure was not linked to an increased risk of childhood allergy or impaired ILF.
  • Despite the lack of direct clinical association, BPA's impact on perinatal immune biomarkers suggests a potential role in allergy development.
  • Further research is needed to fully understand the long-term implications of prenatal BPA exposure on allergic diseases.
Abstract

Keywords:
Bisphenol AChildhood allergyCytokineIgEInfant lung function

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