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Related Experiment Videos

Growth hormone receptors.

L G Mendelsohn1

  • 1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.

Life Sciences
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Researchers purified and cloned the rabbit liver growth hormone (GH) receptor, revealing a new transmembrane protein class. This discovery supports a dual GH action mechanism, impacting both cell differentiation and proliferation.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Biology

Background:

  • The receptor for rabbit liver growth hormone (GH) was purified and cloned.
  • Sequencing revealed a novel transmembrane receptor class with unique glycosylation and ubiquitin linkages.
  • Human liver GH receptor homology is high (84%), but non-liver GH receptor functions and homology remain unclear.

Purpose of the Study:

  • To characterize the novel rabbit liver growth hormone receptor.
  • To investigate the functional implications of GH receptor presence in different cell types.
  • To evaluate the hypothesis of a dual mechanism of GH action.

Main Methods:

  • Purification and cloning of the rabbit liver GH receptor.
  • DNA sequencing and homology analysis.

Related Experiment Videos

  • Review of existing literature on GH effects in preadipocytes and bone cells.

    • Main Results:

    • The rabbit liver GH receptor is a new class of transmembrane proteins.
    • Significant homology (84%) exists between rabbit and human liver GH receptors.
    • GH directly stimulates preadipocyte differentiation and binds to resting bone cells, not proliferative layers.

    Conclusions:

    • The rabbit liver GH receptor represents a distinct class of transmembrane proteins.
    • GH exhibits a dual mechanism of action: direct precursor cell differentiation and enhanced proliferative response.
    • Further research is needed to understand non-liver GH receptor functions and homology.