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Updated: Dec 9, 2025
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
[Reduction of Visitor- and Staff-Associated Risk of Infection by Complex Intervention in the Department of
Gregor Seliger1, Inna Krol1, Dieter Worlitzsch2
1Universitätsklinik und Poliklinik für Geburtshilfe und Pränatalmedizin, Martin-Luther-Universität Halle-Wittenberg, Halle.
Aim:
Clinical trial registration of this trial: is to demonstrate in a department of feto-maternal medicine: (a) that a complex intervention improves hand hygiene of visitors, siblings and staff; and (b) that automated voice prompts at disinfectant dispensers improve rate of hand disinfection.
Study Design:
(a) Pre-/post-test follow-up design with control (1-12/2016), intervention (1-12/2017), follow-up-period (1/2018-12/2019); and (b) RCT in quasi crossover design. Primary endpoints: (a) disinfectant consumption (DC) per patient-day, and (b) DC at disinfectant dispenser per passer-by.
Results:
A multimodal strategy within the intervention period showed a relevant positive effect on hand hygiene compliance (in IP: 26.2% more DC; p=0.088). Voice prompts increased DC by 28.6% (p=0.025). The odds ratio for high positive fingertip testing plates of visiting children (siblings) between control and intervention period was 0.35 (95% CI [0.1074-0.9708] p=0.039).
Conclusion:
Complex intervention and electronic voice prompts on disinfectant dispensers improve hand hygiene behaviour in perinatology. Installation of disinfectant dispensers in a child-friendly position and adequate information material appeal to children. The data represent an important contribution to improve hand hygiene of visitors, siblings and staff in hospitals in a pandemic situation.
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