Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

4.0K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.0K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

11.1K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
11.1K
Liver Physiology01:30

Liver Physiology

3.2K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.2K
Introduction to Hemostasis01:05

Introduction to Hemostasis

12.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
12.2K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.8K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.8K
Hepatic Portal System01:21

Hepatic Portal System

4.5K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International consensus on mesopancreas and total mesopancreas excision (MESODELPHI).

HPB : the official journal of the International Hepato Pancreato Biliary Association·2026
Same author

Long-Term Outcomes and Surgical Conversion After Immunotherapy in Microsatellite Instability-H Biliary Tract Cancers.

JCO precision oncology·2026
Same author

ASO Author Reflections: Baseline Liver Function and Long-Term Outcomes After Resection for Biliary Tract Cancer.

Annals of surgical oncology·2026
Same author

ASO Visual Abstract: The Effect of Neoadjuvant Therapy on Post-Recurrence Overall Survival After Curative Resection for Intrahepatic Cholangiocarcinoma.

Annals of surgical oncology·2026
Same author

Baseline Liver Function Predicts Long-Term Survival Beyond Perioperative Outcomes After Liver Resection for Biliary Tract Cancer.

Annals of surgical oncology·2026
Same author

ASO Author Reflections: Neoadjuvant Therapy and Post-Recurrence Overall Survival in Intrahepatic Cholangiocarcinoma.

Annals of surgical oncology·2026

Related Experiment Video

Updated: Dec 9, 2025

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
08:14

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration

Published on: May 20, 2015

9.0K

Hemostasis and Liver Regeneration.

Patrick Starlinger1,2, James P Luyendyk3, Dafna J Groeneveld3

  • 1Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.

Seminars in Thrombosis and Hemostasis
|September 9, 2020
PubMed
Summary

The liver

Area of Science:

  • Hepatology and regenerative medicine.
  • Hemostasis and thrombosis research.
  • Surgical oncology and liver disease management.

Background:

  • The liver possesses significant regenerative capabilities, allowing for surgical interventions like liver resection for diseases such as neoplastic liver disease.
  • Following partial hepatectomy, the remaining liver tissue (liver remnant) regenerates to restore normal hepatic function.
  • While hemostatic complications are often viewed as surgical risks, the hemostatic system plays a crucial role in liver regeneration.

Purpose of the Study:

  • To review clinical and translational evidence linking the hemostatic system to liver regeneration.
  • To explore the mechanisms by which the hemostatic system influences liver regeneration, based on experimental findings.

Main Methods:

  • Review of existing clinical and translational studies.

More Related Videos

The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.7K
Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice
10:04

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

5.2K

Related Experiment Videos

Last Updated: Dec 9, 2025

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
08:14

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration

Published on: May 20, 2015

9.0K
The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.7K
Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice
10:04

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

5.2K
  • Analysis of experimental data on liver regeneration mechanisms.
  • Synthesis of evidence on the role of hemostatic factors in liver repair.

    • Main Results:

    • The hemostatic system, including components involved in bleeding and thrombosis, actively drives liver regeneration.
    • Experimental models and clinical observations demonstrate a strong connection between hemostasis and the regenerative process of the liver.
    • Fundamental signaling pathways governing hepatocyte proliferation are being elucidated, with hemostatic factors emerging as key regulators.

    Conclusions:

    • The hemostatic system is not merely associated with surgical complications but is a critical determinant of successful liver regeneration.
    • Understanding these mechanisms offers potential therapeutic targets for enhancing liver repair after resection.
    • Further research into the interplay between hemostasis and liver regeneration is warranted for clinical applications.