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p53 increases experimental metastatic capacity of murine carcinoma cells
J Pohl1, N Goldfinger, A Radler-Pohl
1Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg.
Molecular and Cellular Biology
|May 1, 1988
Abstract:
Transfection of a cloned p53 gene into a murine bladder carcinoma cell with a low metastatic capacity led to elevated levels of p53 protein in clonal transfectants. After intravenous inoculation into syngeneic mice, p53-transfected clones showed significantly increased metastatic potential in comparison with control transfectants. The observed change did not seem to be due to a change in growth potential per se since the cell lines showed similar growth properties in vitro.