Orbital and Eyelid B-Cell Lymphoma: A Multicenter Retrospective Study

Area of Science:

• Oncology
• Ophthalmology
• Hematology

Background:

• Orbital and eyelid B-cell lymphoma (OEL) is a rare malignancy.
• Understanding OEL subtypes and treatment is crucial for patient outcomes.

Purpose of the Study:

• To analyze histopathologic findings, risk factors, and treatments for OEL.
• To correlate these factors with OEL recurrence and progression-free survival (PFS).

Main Methods:

• Retrospective analysis of 141 OEL cases.
• Evaluation of histopathology, risk factors, treatment type, and PFS.
• Statistical correlation of factors with OEL recurrence and PFS.

Main Results:

• Extranodal marginal zone B-cell lymphoma was the most common subtype (66%).
• Diffuse large B-cell lymphoma (DLBCL) and chemotherapy treatment were associated with a higher probability of relapse.
• Multivariate analysis confirmed DLBCL and chemotherapy as significant predictors of poorer PFS.

Conclusions:

• Five OEL subtypes were identified.
• Histopathologic subtype and treatment modality are key determinants of treatment outcomes in OEL.
• DLBCL subtype and chemotherapy confer a poorer PFS in OEL.