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Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs
Sundus Riaz1,2, Nosheen Fatima Rana1, Irshad Hussain3
1Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, Pakistan.
Nanomaterials (Basel, Switzerland)
|September 10, 2020
Summary
Flavonoid-coated gold nanoparticles effectively reduced Enterococcus faecalis in mouse organs. This study highlights nano drug delivery systems as a promising approach against multidrug resistance in internal infections.
Area of Science:
- Nanotechnology
- Pharmacology
- Microbiology
Background:
- Multidrug resistance (MDR) necessitates novel therapeutic strategies.
- Nano drug delivery systems offer potential solutions for antibiotic resistance.
- Limited research exists on the in-vivo efficacy and toxicity of antibacterial nanocarriers within host tissues.
Purpose of the Study:
- To investigate the efficacy of flavonoid-coated gold nanoparticles (FAuNPs) against Enterococcus faecalis colonization in mouse liver and kidneys.
- To evaluate the antibacterial effects of FAuNPs in both in-vitro and in-vivo settings.
- To assess the potential of green-synthesized FAuNPs as a biocompatible antibacterial agent.
Main Methods:
- Green synthesis of gold nanoparticles stabilized with flavonoids extracted from Berberis lycium leaves.
- Characterization of FAuNPs using UV-Vis spectroscopy, FTIR, STEM, XRD, and EDS.
- In-vitro and in-vivo evaluation of FAuNPs against Enterococcus faecalis in mouse organs.
Main Results:
- FAuNPs demonstrated significantly higher reduction in bacterial counts compared to free flavonoids.
- The study confirmed the biocompatibility and effectiveness of FAuNPs.
- FAuNPs successfully reduced Enterococcus faecalis colonization in mouse liver and kidneys.
Conclusions:
- Flavonoid-coated gold nanoparticles are effective antibacterial agents against Enterococcus faecalis.
- FAuNPs show promise for treating internal infections caused by multidrug-resistant bacteria.
- Green synthesis of FAuNPs presents a viable approach for developing novel nanomedicines.
