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Sensitivity enhancement of a fiber-based interferometric optofluidic sensor
Optics Express
|September 10, 2020
Summary
This study enhances optofluidic sensor sensitivity for point-of-care testing. Optimizing geometry significantly boosts refractive index sensitivity, enabling highly sensitive biomolecule detection.
Area of Science:
- Photonics and micro/nanofluidics integration
- Optofluidic sensor development
- Biomedical sensing technologies
Background:
- Optofluidic sensors bridge photonics and microfluidics for point-of-care diagnostics.
- Fiber-based interferometric optofluidic (FIO) sensors offer sensitive biomolecule detection.
- Quantitative understanding of light-fluid interaction sensitivity is needed.
Purpose of the Study:
- To theoretically and experimentally investigate refractive index (RI) sensitivity in FIO sensors.
- To determine the relationship between RI sensitivity and geometrical parameters.
- To optimize lateral localized light-fluid evanescent interaction for enhanced detection.
Main Methods:
- Theoretical analysis of FIO sensor parameters.
- Experimental investigation of geometrical effects on sensitivity.
- Precise control of fiber diameter (d) and tube wall thickness (t).
Main Results:
- A maximum RI sensitivity was theoretically predicted.
- Optimized geometry achieved an extremely high RI sensitivity of 1.6×10^4 nm/RIU.
- A detection limit of 3.0×10^-6 RIU was recorded, an order of magnitude improvement.
Conclusions:
- Synergistic tuning of geometrical parameters is crucial for maximizing FIO sensor sensitivity.
- The findings provide guidance for designing advanced optofluidic devices and biomedical sensors.
- This work advances the field of sensitive and portable diagnostic tools.
