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Related Concept Videos

Cell Adhesion in Plants01:14

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
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Updated: Dec 9, 2025

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
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Controlling cell adhesion on polyurethanes.

T Joseph Dennes1, Jeffrey Schwartz1

  • 1Department of Chemistry, Princeton University, Princeton, NJ 08544, U. S. A. jschwartz@princeton.edu.

Soft Matter
|September 10, 2020
PubMed
Summary
This summary is machine-generated.

Polyurethane device surfaces can be modified using zirconium tetra(tert-butoxide) to control cell interactions. This method allows for nanoscale surface property tuning without affecting the material's bulk characteristics.

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Surface Chemistry

Background:

  • Controlling surface properties of medical devices is crucial for biocompatibility.
  • Polyurethanes are widely used in medical devices but often require surface modification for specific cellular interactions.

Purpose of the Study:

  • To develop a method for controlling polyurethane surface properties at the nanoscale.
  • To functionalize polyurethane surfaces with cell-interactive peptides and non-interactive polymers.

Main Methods:

  • Treatment of polyurethane surfaces with zirconium tetra(tert-butoxide) to create reactive interfacial zirconium complexes.
  • Subsequent bonding of cell-attractive peptides (arginine-glycine-aspartic acid - RGD) and cell-non-attractive polymers (polyethylene glycol - PEG) to the surface via the zirconium complexes.
  • Characterization of surface loading and coverage using techniques sensitive to nanoscale modifications.

Main Results:

  • Zirconium complex formation occurs at N-H sites on the polyurethane backbone, influencing surface loading.
  • Achieved significant zirconium complex loading on poly(hexamethylenehexylene)urethane and tecoflex®.
  • Demonstrated nanoscale surface coverage with RGD (10-25%) and PEG (approx. 100%) without compromising bulk polymer properties.

Conclusions:

  • Zirconium-based surface modification offers a versatile method for tuning polyurethane biocompatibility.
  • The approach allows for precise control over the nanoscale surface chemistry, enabling tailored cell adhesion properties.
  • This technique holds promise for developing advanced medical devices with improved biological performance.