Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Azathioprine in multiple sclerosis: the cons.

D H Silberberg1

  • 1Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104.

Neurology
|July 1, 1988
PubMed
Summary

Azathioprine shows limited evidence of effectiveness for multiple sclerosis (MS) treatment. Ongoing trials should be completed before further azathioprine studies in MS are considered due to potential risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adult human brain expresses four different molecular forms of neural cell adhesion molecules.

Neurochemistry international·2010
Same author

Immunologic characterization of oligodendroglia.

Neuroscience letters·2009
Same author

Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines [RETIRED].

Neurology·2002
Same author

A double-blind, placebo-controlled trial of extracorporeal photopheresis in chronic progressive multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·1999
Same author

Specific treatment of multiple sclerosis.

Clinical neuroscience (New York, N.Y.)·1994
Same author

Corticosteroids and optic neuritis.

The New England journal of medicine·1993

Area of Science:

  • Neuroimmunology
  • Clinical Pharmacology

Background:

  • Azathioprine is a long-standing immunosuppressive treatment for multiple sclerosis (MS).
  • Numerous clinical trials have investigated azathioprine's efficacy in MS management.

Purpose of the Study:

  • To review existing clinical trial data on azathioprine in multiple sclerosis.
  • To evaluate the evidence for azathioprine's therapeutic benefit and safety in MS.

Main Methods:

  • Systematic review of reported clinical trials for azathioprine in MS.
  • Analysis of evidence regarding therapeutic effects and adverse events.

Main Results:

  • Limited evidence supports a therapeutic effect of azathioprine in multiple sclerosis.
  • Concerns exist regarding the drug's risk profile, including potential increased carcinoma incidence.

Conclusions:

  • The current evidence does not strongly support azathioprine use in MS.
  • Completion of ongoing trials is recommended before initiating new azathioprine studies in MS.

Related Experiment Videos