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Updated: Dec 9, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
Three-dimensional imaging through scattering media based on confocal diffuse tomography
David B Lindell1, Gordon Wetzstein2
1Department of Electrical Engineering, Stanford University, 350 Jane Stanford Way, Stanford, CA, 94305, USA. lindell@stanford.edu.
Abstract:
Optical imaging techniques, such as light detection and ranging (LiDAR), are essential tools in remote sensing, robotic vision, and autonomous driving. However, the presence of scattering places fundamental limits on our ability to image through fog, rain, dust, or the atmosphere. Conventional approaches for imaging through scattering media operate at microscopic scales or require a priori knowledge of the target location for 3D imaging. We introduce a technique that co-designs single-photon avalanche diodes, ultra-fast pulsed lasers, and a new inverse method to capture 3D shape through scattering media. We demonstrate acquisition of shape and position for objects hidden behind a thick diffuser (≈6 transport mean free paths) at macroscopic scales. Our technique, confocal diffuse tomography, may be of considerable value to the aforementioned applications.
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