Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.2K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IL-13 signaling in cDC2 is required for systemic anaphylactic responses.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Speech-in-noise recognition during hearing protector use: Human performance and acoustic prediction.

Hearing research·2026
Same author

Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation.

eLife·2026
Same author

CDO1 is a new biomarker to discriminate aggressive forms of prostate cancer.

Oncogene·2026
Same author

Oncogenic PIK3CA mutations shape an immunoregulatory microenvironment in mosaic overgrowth disorders.

PNAS nexus·2026
Same author

Charting spatial ligand-target activity using Renoir.

Nature communications·2026

Related Experiment Video

Updated: Dec 9, 2025

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice
04:29

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Published on: July 1, 2022

10.3K

Genetic models of human and mouse dendritic cell development and function.

David A Anderson1, Charles-Antoine Dutertre2, Florent Ginhoux2,3,4

  • 1Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

Nature Reviews. Immunology
|September 10, 2020
PubMed
Summary

This study explores dendritic cell (DC) development and function, comparing mouse models to human counterparts. Findings help correlate DC ontogeny with their roles in immunity, particularly in T cell polarization and viral detection.

More Related Videos

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

11.0K
Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging
13:13

Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging

Published on: July 9, 2008

31.5K

Related Experiment Videos

Last Updated: Dec 9, 2025

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice
04:29

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Published on: July 1, 2022

10.3K
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

11.0K
Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging
13:13

Generation of Bone Marrow Derived Murine Dendritic Cells for Use in 2-photon Imaging

Published on: July 9, 2008

31.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • Dendritic cells (DCs) originate from bone marrow hematopoietic progenitors with conserved features in mice and humans.
  • DCs are broadly classified into classical DCs (type 1 and type 2) and plasmacytoid DCs, each with distinct functions.
  • Classical DCs present antigens to polarize naive CD8+ or CD4+ T cells, while plasmacytoid DCs primarily detect viral infections and produce type I interferon.

Purpose of the Study:

  • To review genetic models of mouse dendritic cell development and function.
  • To correlate dendritic cell ontogeny with specific immune functions.
  • To translate findings from mouse models to human dendritic cells and their progenitors.

Main Methods:

  • Review of genetic models in mice.
  • Analysis of transcriptional signatures and developmental potential.
  • Comparative analysis between mouse and human dendritic cell progenitors.

Main Results:

  • Mouse genetic models provide insights into dendritic cell ontogeny and function.
  • Shared characteristics facilitate translation of findings between species.
  • Understanding DC development aids in deciphering their roles in adaptive and innate immunity.

Conclusions:

  • Dendritic cell development and function are conserved across species.
  • Genetic models are crucial for understanding dendritic cell biology.
  • Further research can bridge the gap between mouse and human dendritic cell understanding for therapeutic applications.