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Vitamin D and Hyperkinetic Movement Disorders: A Systematic Review
Carl N Homann1,2, Gerd Ivanic3, Barbara Homann1
1Department of Neurology, Medical University Graz, Graz, AT.
Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|September 10, 2020
Summary
Vitamin D deficiency is common in hyperkinetic movement disorders (HKMDs), affecting up to 89% of patients. Testing and supplementation are recommended for HKMDs patients, especially those with a history of falls.
Area of Science:
- Neurology
- Endocrinology
- Bone Metabolism
Background:
- Parkinson's disease research extensively covers vitamin D deficiency.
- The role of vitamin D in other movement disorders remains under-investigated.
- Hyperkinetic movement disorders (HKMDs) may be significantly impacted by vitamin D status.
Purpose of the Study:
- To review the prevalence of vitamin D deficiency in common HKMDs.
- To examine bone metabolism alterations and fracture risks in HKMDs.
- To highlight the under-investigated nature of these issues in HKMDs.
Main Methods:
- Systematic review of studies.
- Literature search conducted on PubMed.
- Keywords included common HKMDs, vitamin D, osteoporosis, and fractures.
Main Results:
- 40 studies were included from 1585 screened.
- Vitamin D deficiency found in up to 89% of patients with HKMDs like Huntington disease, Restless Legs Syndrome, and tremor.
- Reduced bone mineral density noted in Huntington disease patients with vitamin D insufficiency.
Conclusions:
- Vitamin D deficiency, bone changes, and fractures are significant issues in HKMDs.
- These conditions are currently under-investigated in HKMDs.
- Testing and supplementation of vitamin D are recommended for HKMDs patients, particularly those with falls.
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