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Updated: Dec 9, 2025
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Identification of microRNA-451a as a Novel Circulating Biomarker for Colorectal Cancer Diagnosis
Zhen Zhang1, Dai Zhang2, Yaping Cui1
1Department of Anesthesiology, Affiliated Cancer Hospital of ZhengZhou University, Henan Cancer Hospital, ZhengZhou, China.
Background:
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Successful treatment of CRC relies on accurate early diagnosis, which is currently a challenge due to its complexity and personalized pathologies. Thus, novel molecular biomarkers are needed for early CRC detection.
Methods:
Gene and microRNA microarray profiling of CRC tissues and miRNA-seq data were analyzed. Candidate microRNA biomarkers were predicted using both CRC-specific network and miRNA-BD tool. Validation analyses were carried out to interrogate the identified candidate CRC biomarkers.
Results:
We identified miR-451a as a potential early CRC biomarker circulating in patient's serum. The dysregulation of miR-451a was revealed both in primary tumors and in patients' sera. Downstream analysis validated the tumor suppressor role of miR-451a and high sensitivity of miR-451a in CRC patients, further confirming its potential role as CRC circulation biomarker.
Conclusion:
The miR-451a is a potential circulating biomarker for early CRC diagnosis.
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