Dyslipidemia in Pediatric Type 2 Diabetes Mellitus

Related Experiment Video

Updated: Dec 9, 2025

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.5K

Bhuvana Sunil1, Ambika P Ashraf2

  • 1Department of Pediatrics, Division of Endocrinology and Diabetes, University of Alabama at Birmingham, CPPII M30, 1601 4th Ave S, Birmingham, AL, 35233, USA.

Current Diabetes Reports
|September 10, 2020
PubMed

Insights

Children with type 2 diabetes mellitus (T2D) often have dyslipidemia, a risk factor for cardiovascular disease. This review covers dyslipidemia

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Cardiovascular disease is a leading cause of death in type 2 diabetes mellitus (T2D).
  • Dyslipidemia is common in pediatric T2D and is a significant risk factor for cardiovascular disease (CVD).
  • Understanding dyslipidemia in T2D is crucial for preventing long-term complications.

Purpose of the Study:

  • To review the epidemiology and pathophysiology of dyslipidemia in pediatric T2D.
  • To examine current recommendations for managing dyslipidemia in this population.
  • To highlight gaps in current risk assessment and management strategies.

Main Methods:

  • Literature review of epidemiological data.
  • Analysis of pathophysiological mechanisms linking T2D and dyslipidemia.
  • Critique of existing clinical guidelines for lipid management.

Main Results:

  • Dyslipidemia in pediatric T2D is multifactorial, influenced by glycemic control, insulin resistance, inflammation, and genetics.
  • Current guidelines suggest lipid screening post-glycemic control, with specific targets for LDL-C, HDL-C, and TG.
  • Statins and fibrates are recommended for specific lipid level thresholds, but other atherogenic lipoproteins are often overlooked.

Conclusions:

  • Effective management of dyslipidemia is essential for reducing CVD risk in children with T2D.
  • Current guidelines provide a framework but may not fully address the complexity of dyslipidemia in this cohort.
  • Further research and updated guidelines are needed to incorporate a comprehensive assessment of lipid parameters for optimal patient care.
Abstract

Keywords:
Cardiovascular riskDyslipidemiaInsulin resistancePediatricType 2 diabetes

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.6K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.9K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.6K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
108
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.8K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
168
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.8K