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Radiation: Applications01:17

Radiation: Applications

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The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
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Prostate re-irradiation: current concerns and future perspectives.

Francesco Cuccia1, Rosario Mazzola1, Luca Nicosia1

  • 1Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Negrar , Verona, Italy.

Expert Review of Anticancer Therapy
|September 10, 2020
PubMed
Summary

Re-irradiation with external beam radiotherapy (EBRT), particularly stereotactic body radiotherapy (SBRT), shows promise for managing locally relapsed prostate cancer. This approach may delay hormone therapy and appears safe, with promising early outcomes.

Keywords:
Prostate cancerexternal beam radiotherapylocal relapsere-irradiationstereotactic body radiotherapy

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Urology

Background:

  • Optimal management for locally relapsed prostate cancer post-radiotherapy is debated.
  • Local therapies may delay androgen-deprivation therapy initiation.
  • External beam radiotherapy (EBRT) re-irradiation is increasingly explored.

Purpose of the Study:

  • Systematic review of EBRT for locally relapsed prostate cancer.
  • Evaluate safety, tolerability, and clinical outcomes of re-irradiation.
  • Assess stereotactic body radiotherapy (SBRT) as a treatment option.

Main Methods:

  • Systematic literature review using PICO methodology.
  • Analysis of studies on EBRT re-treatment for prostate cancer recurrence.
  • Focus on extreme hypofractionated schedules (SBRT).

Main Results:

  • EBRT, especially SBRT, is a feasible and safe re-treatment option.
  • Extreme hypofractionation with SBRT shows occasional grade ≥3 late adverse events.
  • Preliminary clinical outcomes are promising for recurrent prostate cancer.

Conclusions:

  • SBRT is a safe and feasible option for re-treating locally recurrent prostate cancer.
  • Further prospective studies are warranted to evaluate SBRT.
  • SBRT may serve as an alternative to early androgen-deprivation therapy.