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Diffusion tensor imaging indices to predict cognitive changes following adult radiotherapy.
Noorazrul Yahya1, Hanani A Manan2
1Diagnostic Imaging and Radiotherapy, Faculty of Health Sciences, National University of Malaysia, Kuala Lumpur, Malaysia.
European Journal of Cancer Care
|September 10, 2020
Summary
Diffusion tensor imaging (DTI) can detect radiation-induced white matter changes. Decreased fractional anisotropy (FA) in specific brain regions predicts cognitive decline after radiotherapy.
Area of Science:
- Neuroimaging
- Radiotherapy Research
- Cognitive Neuroscience
Background:
- High-dose radiation can impact white matter tracts.
- Diffusion tensor imaging (DTI) is sensitive to these microstructural changes.
- Cognitive decline is a known sequela of radiotherapy.
Purpose of the Study:
- To systematically evaluate DTI indices for predicting cognitive changes after adult radiotherapy.
- To identify specific DTI biomarkers associated with radiotherapy-induced cognitive impairment.
Main Methods:
- Systematic literature search of PubMed and Scopus databases adhering to PRISMA guidelines.
- Extraction of data on patient demographics, DTI metrics, and cognitive outcomes from eligible studies.
- Analysis of associations between DTI changes and cognitive performance.
Main Results:
- Six studies involving 110 patients were included.
- Five studies reported significant cognitive decline post-radiotherapy.
- Decreased fractional anisotropy (FA) was consistently linked to cognitive decline, particularly in the cingulum and corpus callosum.
Conclusions:
- Fractional anisotropy (FA) serves as a clinically relevant biomarker for radiotherapy-related cognitive decline.
- Larger patient cohorts are required to validate these findings and inform therapeutic interventions.
- Further research is needed to develop strategies to mitigate radiation-induced cognitive impairment.
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