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Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
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Ocular surgery after herpes simplex and herpes zoster keratitis
Piotr Kanclerz1, Jorge L Alio2
1Hygeia Clinic, Gdańsk, Poland.
International Ophthalmology
|September 10, 2020
Summary
Perioperative oral antiviral prophylaxis is recommended after penetrating keratoplasty for patients with a history of herpetic stromal keratitis (HSK) or herpes zoster ophthalmicus (HZO). Evidence for other surgeries is less compelling but warrants consideration.
Area of Science:
- Ophthalmology
- Virology
- Corneal Surgery
Background:
- Herpetic stromal keratitis (HSK) and herpes zoster ophthalmicus (HZO) can recur after various ocular surgeries.
- Ocular surgeries can disrupt corneal nerves and alter immune responses, potentially triggering HSK/HZO reactivation.
Purpose of the Study:
- To review evidence on perioperative preventive methods for HSK/HZO recurrence in patients undergoing ocular surgery.
- To assess the risk and prophylaxis strategies for HSK/HZO recurrence post-eye surgery.
Main Methods:
- Systematic literature search of PubMed and Web of Science databases.
- Inclusion of articles on HSK/HZO prophylaxis and recurrence risk up to December 31, 2019.
Main Results:
- Ocular surgeries like keratoplasty, cataract surgery, and refractive procedures can disturb corneal nerves, increasing HSK/HZO recurrence risk.
- Strong evidence supports oral antiviral prophylaxis post-penetrating keratoplasty for HSK/HZO patients.
- Prophylaxis and disease quiescence are advisable for other surgeries, though evidence is less robust.
Conclusions:
- Evidence for HSK/HZO prophylaxis in ocular surgery is discussed.
- Further research is needed to clarify HSK/HZO recurrence risk, especially after cataract surgery, and validate prophylaxis efficacy.
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