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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

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Multidisciplinary Management of Cancer During Pregnancy.

Jordyn Silverstein¹, Annalisa L Post², A Jo Chien^1,3

¹Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.

JCO Oncology Practice

|September 10, 2020

Summary

Cancer in pregnant women is increasing. Management requires balancing maternal treatment benefits against fetal risks, involving multidisciplinary teams and careful consideration of therapies and gestational age.

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Area of Science:

Oncology
Maternal-Fetal Medicine
Reproductive Health

Background:

Cancer during pregnancy is a growing concern due to rising maternal age.
Managing cancer in pregnancy involves complex ethical and medical decisions, balancing maternal care with fetal well-being.
Diagnostic evaluations are generally safe during pregnancy and should not be deferred.

Purpose of the Study:

To review current data on anticancer therapies for pregnant patients.
To outline key principles for managing cancer diagnosed during pregnancy.
To discuss considerations for oncologic management tailored to pregnancy.

Main Methods:

Literature review summarizing data on anticancer therapies.
Discussion of management considerations for selected cancers in pregnancy.
Analysis of factors influencing treatment decisions, including cancer type, stage, tumor biology, and gestational age.

Main Results:

Diagnostic evaluations can often be safely performed during pregnancy.
Noninvasive prenatal testing may indicate underlying maternal malignancy.
Treatment decisions require a multidisciplinary approach, considering maternal prognosis, fetal safety, and gestational age.

Conclusions:

Management of cancer in pregnancy necessitates a multidisciplinary team approach.
Treatment selection depends on cancer characteristics and gestational age, with careful consideration of maternal and fetal outcomes.
Open communication with patients regarding treatment options, including pregnancy termination, is crucial.