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Single Cell Technologies Define New Therapeutic Avenues for Huntington's Disease
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N3Z5, Canada.
Neuron
|September 10, 2020
Abstract:
Using two independent single-cell transcriptomics technologies, Lee et al. have cataloged transcriptional changes in the subset of striatal neurons hit hardest in Huntington's disease. One downregulated pathway, oxidative phosphorylation, may also explain their observed release of mitochondrial-encoded RNAs.
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