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Related Experiment Video

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Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
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A multi-metric approach to characterizing mouse peripheral auditory nerve function using the auditory brainstem

Carolyn M McClaskey1, Clarisse H Panganiban2, Kenyaria V Noble2

  • 1Department of Otolaryngology, Head & Neck Surgery, Medical University of South Carolina, 135 Rutledge Ave, MSC 550, Charleston, SC, 29425, United States.

Journal of Neuroscience Methods
|September 10, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces new methods to assess auditory nerve function in mice using auditory brainstem responses (ABR). These advanced techniques reveal insights into neural synchrony and fiber heterogeneity, aiding hearing loss research.

Keywords:
Auditory brainstem response (ABR)Mouse auditory nerve (AN)Neural synchronySuprathreshold function

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Hearing Research

Background:

  • Auditory brainstem response (ABR), particularly wave I, is a standard for measuring auditory nerve (AN) function noninvasively.
  • Recent human studies have developed advanced electrocochleography to assess AN suprathreshold processing and neural synchrony.

Purpose of the Study:

  • To establish novel in vivo tools for evaluating AN function in adult mice.
  • To adapt human-derived electrophysiological methods for use in a common animal model.

Main Methods:

  • Utilized tone-evoked ABRs in CBA/CaJ mice.
  • Obtained six distinct metrics from ABR wave I at suprathreshold stimulus levels.
  • Applied change-point analyses to assess the rate of metric change with stimulus level.

Main Results:

  • Identified distinct changes in the rate of metric change between moderate and high suprathreshold levels.
  • Demonstrated the potential to characterize heterogeneous AN fiber types.
  • Provided evidence of neural synchrony deficits and altered AN fiber heterogeneity.

Conclusions:

  • Developed a novel, translational tool for assessing AN function in vivo in mice.
  • Enabled the study of AN dysfunction in animal models with known pathologies.
  • Facilitated prediction of human AN dysfunction and hearing loss based on animal model findings.