Related Experiment Video
Updated: Dec 9, 2025

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
Published on: June 12, 2020
Persistently elevated hCG in a patient with no clear evidence of pregnancy
Caroline Miller1, Miriam McQuade2, Julia MacCallum2
1Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, United States.
Background:
We describe a case of a female patient with a complex medical history, including squamous cell carcinoma of the tongue, and persistent elevation in serum hCG and no confirmed intrauterine or extrauterine pregnancy.
Methods:
The clinical chemistry laboratory was called upon to help clarify the situation and reach a diagnosis.
Results:
Multiple potential sources of elevated hCG were considered and excluded.
Conclusions:
This case shows a rare example of paraneoplastic hCG expression and highlights the role of the clinical chemistry laboratory in resolving diagnostic dilemmas and interpreting laboratory results in patients with multiple medical comorbidities.
More Related Videos
07:20Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
Published on: December 21, 2012
05:16Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Related Concept Videos
Ovarian Cycle
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Oogenesis
Cardiomyopathy III: Hypertrophic Cardiomyopathy