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Trends in US hospitalizations for anaphylaxis among infants and toddlers: 2006 to 2015

Lacey B Robinson1, Anna Chen Arroyo2, Mohammad Kamal Faridi3

  • 1Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|September 10, 2020
PubMed

Insights

US infant and toddler anaphylaxis hospitalizations remained stable from 2006-2015, unlike older children whose rates increased. Further research is needed on this young population.

Area of Science:

  • Pediatric Allergy and Immunology
  • Public Health Trends
  • Epidemiology

Background:

  • Anaphylaxis, a severe allergic reaction, has increasing prevalence.
  • US hospitalization trends for anaphylaxis in infants and toddlers are not well understood.

Purpose of the Study:

  • To analyze US hospitalization trends for anaphylaxis in young children (under 3 years).
  • To identify predictors of anaphylaxis hospitalizations in infants and toddlers.

Main Methods:

  • Analysis of the National Inpatient Sample (NIS) from 2006-2015.
  • Inclusion of patients with anaphylaxis using ICD-9-CM codes.
  • Multivariable logistic regression to identify predictors in infants and toddlers.

Main Results:

  • Anaphylaxis hospitalizations in infants and toddlers showed no significant trend (P=0.14).
  • Hospitalizations were more common in males, privately insured, higher income, with chronic pulmonary disease, and in urban Northeast teaching hospitals.
  • In contrast, anaphylaxis hospitalizations rose significantly in older children (3-18 years, P<0.001).

Conclusions:

  • US anaphylaxis hospitalizations for infants and toddlers were stable between 2006-2015.
  • Hospitalizations for older children increased during the same period.
  • Further research on disease prevalence and healthcare use in young children is recommended.
Abstract

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