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Updated: Dec 9, 2025
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
907
Metabolomics: An emerging potential approach to decipher critical illnesses
Mohd Adnan Siddiqui1, Swarnima Pandey2, Afzal Azim3
1Centre of Biomedical Research, SGPGIMS Campus, Lucknow 226014, India; Department of Bioengineering, Integral University, Lucknow 226026, India.
Biophysical Chemistry
|September 10, 2020
Summary
Metabolomics shows promise for identifying rapid diagnostic and prognostic biomarkers for critical illnesses like acute respiratory distress syndrome (ARDS) and sepsis/septic shock, improving patient care.
Area of Science:
- Critical care medicine
- Biomarker discovery
- Metabolomics
Background:
- Critical illnesses, including acute respiratory distress syndrome (ARDS) and sepsis/septic shock, are leading causes of hospital morbidity and mortality.
- Both ARDS and sepsis share underlying mechanisms of inflammation and endothelial dysfunction.
- Current diagnostic methods for ARDS and sepsis have limitations, including time delays and low yields, necessitating improved tools.
Purpose of the Study:
- To review the potential of metabolomics in identifying novel biomarkers for ARDS and sepsis/septic shock.
- To explore the utility of metabolomic biomarkers for rapid diagnosis and prognosis in critically ill patients.
- To assess the current scientific data supporting metabolomics in these specific patient populations.
Main Methods:
- Literature review of scientific data on metabolomics and critical illnesses.
- Analysis of existing studies investigating biomarkers for ARDS and sepsis.
- Focus on metabolomic approaches for biomarker discovery and validation.
Main Results:
- Metabolomics offers a promising avenue for discovering rapid diagnostic and prognostic biomarkers.
- Specific metabolic profiles may differentiate between ARDS and sepsis/septic shock.
- The identified biomarkers have the potential for clinical application in targeted patient groups.
Conclusions:
- Metabolomics can provide rapid, clinically useful biomarkers for ARDS and sepsis/septic shock.
- Further research is needed to validate and implement these metabolomic biomarkers in clinical practice.
- This approach could significantly improve the management of critically ill patients.
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