Quantitative perfusion parameters of benign inflammatory breast pathologies: A descriptive study

With this study, we evaluated the perfusion magnetic resonance imaging (MRI) features of benign inflammatory breast lesions for the first time and compared their K_trans, K_ep, V_e values and contrast kinetic curves to benign masses and invasive ductal carcinoma (IDC).

Perfusion MRIs of the benign masses (n = 42), inflammatory lesions (n = 25), and IDCs (n = 16) were evaluated retrospectively in terms of K_trans, K_ep, V_e values and contrast kinetic curves and compared by the Kruskal-Wallis, Mann-Whitney U, chi-square tests statistically. Cronbach α test was used to measure intraobserver and interobserver reliability.

Mean K_trans values were 0.052 for benign masses, 0.086 for inflammatory lesions and 0.101 for IDC (p < 0.001). Mean K_ep values were 0.241 for benign masses, 0.435 for inflammatory lesions and 0.530 for IDC (p < 0.001). Mean V_e values were 0.476 for benign masses, 0.318 for inflammatory lesions and 0.310 for IDC (p = 0.067). For inflammatory and IDC lesions, K_trans and K_ep values were found to be higher and V_e values were lower than benign masses (p = 0.001 for K_trans, p = 0.001 for K_ep, p = 0.045 for V_e). There were excellent or good intra-interobserver reliabilities. For the kinetic curve pattern, most of the benign lesions showed progressive (81%), inflammatory lesions progressive (64%) and IDC lesions plateau (75%) patterns (p < 0.001).

On T1 perfusion MRI, similar to IDC lesions, inflammatory lesions demonstrate higher K_trans and K_ep and lower V_e values than benign masses. Quantitative perfusion parameters are not helpful in differentiating them from IDC lesions.