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A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation

Jonathan Poh1, Amy H Ponsford1, James Boyd1

  • 1Institute of Translational Medicine, University of Liverpool, UK.

Redox Biology
|September 10, 2020
PubMed
Summary

This study maps the human NRF2 interactome, identifying new partners that regulate its activity. Over 77% of these new partners modify NRF2 responses, offering insights into disease and drug resistance.

Keywords:
Binary interactomeDual luminescence-based co-immunoprecipitation (DULIP)Fluorescence cross-correlation spectroscopy (FCCS)Human disease networkKEAP1NRF2/NFE2L2Protein interaction network (PIN)

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