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Polyphenols vs. Coronaviruses: How Far Has Research Moved Forward?
Simona Piccolella1, Giuseppina Crescente1, Shadab Faramarzi1
1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.
Phenols and polyphenols show potential antiviral activity against coronaviruses (CoVs). This review examines in vitro data on natural compounds targeting viral proteases, offering insights for future research.
Area of Science:
- Pharmacology
- Virology
- Natural Products Chemistry
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, significantly disrupted research activities.
- This review was motivated by the need to continue scientific inquiry during home confinement.
Purpose of the Study:
- To review recent in vitro data on the antiviral properties of phenols and polyphenols against coronaviruses (CoVs).
- To identify potential viral targets for these natural compounds.
Main Methods:
- Literature review of in vitro experimental studies.
- Focus on studies investigating phenols and polyphenols against various CoV species.
- Analysis of identified viral targets.
Main Results:
- Several isolated natural phenols and polyphenols have been screened for their efficacy against CoVs.
- Papain-like and 3-chymotrypsin-like proteases are frequently investigated viral targets.
- In vitro data suggests antiviral potential of these compounds.
Conclusions:
- Phenols and polyphenols represent a promising class of natural compounds with antiviral activity against coronaviruses.
- Targeting viral proteases is a key strategy in developing new antiviral therapies.
- Further research is warranted to explore the therapeutic potential of these compounds.
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