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Related Experiment Video

Updated: Dec 9, 2025

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

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Published on: March 20, 2015

Design of Surface Enhanced Raman Scattering (SERS) Nanosensor Array.

Yaakov Mandelbaum¹, Raz Mottes¹, Zeev Zalevsky^2,3

¹Advanced Laboratory of Electro-Optics (ALEO), Department of Applied Physics/Electro-Optics Engineering, Lev Academic Center, 9116001 Jerusalem, Israel.

Sensors (Basel, Switzerland)

|September 11, 2020

Summary

Researchers developed an advanced Surface-Enhanced Raman Scattering (SERS) nanosensor array for real-time pH imaging. This pH imager enables spatially resolved chemical measurements, crucial for monitoring reactions.

Keywords:

modeling optical nanosensor plasmon real-time detection simulations

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Last Updated: Dec 9, 2025

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Area of Science:

Nanotechnology
Chemical Sensing
Spectroscopy

Background:

Real-time chemical reaction monitoring is essential.
Existing pH measurement methods lack spatial resolution.
Advanced nanosensor arrays offer potential for improved chemical imaging.

Purpose of the Study:

To present an advanced Surface-Enhanced Raman Scattering (SERS) nanosensor array.
To develop a future pH imager for real-time chemical reaction detection.
To enable spatially resolved pH measurements in fluid targets.

Main Methods:

Design and simulation of a SERS pixel array.
Fabrication of nanostructured substrates with projections or cavities.
Structural characterization using Focused Ion Beam (FIB), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM).
Optimization of nanostructure shape and metallic layer thickness (Ag or Au) for maximal enhancement.

Main Results:

Demonstration of an advanced SERS pixel array.
Preliminary experimental results confirming structural characteristics.
Capability for spatially resolved pH measurements in fluid targets.
Tuning of nanostructures and metallic layers for desired wavelength enhancement.

Conclusions:

The developed SERS nanosensor array is a promising platform for pH imaging.
The array architecture allows for optimized responsivity through nanostructure arrangement.
This technology paves the way for real-time monitoring of chemical reactions.