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Juvenile Spondyloarthritis: focus on uveitis
Achille Marino1,2, Pamela F Weiss3,4, Timothy G Brandon4
1Department of Pediatrics, Desio Hospital, Via Mazzini 1, Desio, MB, Italy.
Pediatric Rheumatology Online Journal
|September 11, 2020
Summary
Approximately 11% of juvenile spondyloarthritis patients develop uveitis, often symptomatic. HLA-B27 status did not influence uveitis development or severity in this patient group.
Area of Science:
- Pediatric Rheumatology
- Ophthalmology
- Immunogenetics
Background:
- Juvenile spondyloarthritis (JSpA) encompasses inflammatory arthritides characterized by enthesitis, axial joint involvement, HLA-B27 association, and uveitis.
- Limited data exist on the course and prevalence of uveitis in pediatric JSpA patients.
Purpose of the Study:
- To determine the prevalence of uveitis in a cohort of JSpA patients.
- To investigate the association between HLA-B27 positivity and the occurrence of uveitis and its symptoms in JSpA.
Main Methods:
- A cross-sectional/retrospective study was conducted on 223 JSpA patients.
- Data collected included diagnosis, uveitis presence, symptomatic uveitis, and HLA-B27 status.
Main Results:
- Uveitis was present in 11% of JSpA patients, most commonly in enthesitis-related arthritis (13%).
- Symptomatic uveitis occurred in 79% of affected patients.
- HLA-B27 positivity was observed in 45% of JSpA patients with uveitis and did not correlate with uveitis development or symptomaticity.
Conclusions:
- Uveitis affects about one-tenth of JSpA patients, frequently presenting with symptoms.
- HLA-B27 positivity is not a reliable predictor for uveitis development or its symptomatic nature in JSpA.
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