Related Experiment Video
Updated: Aug 12, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
New approaches in the use of cyclosporine: with particular reference to the liver
1Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, PA.
Abstract:
Liver transplantation in the highly practical form that exists today has been made possible by multiple agent immunosuppression of which the most important component is CsA. Present day practices of immunosuppression are certain to be changed and probably in the near future in order to increase the effectiveness of therapy and to reduce the nephrotoxicity and other side-effects that until now have inhibited further applications. The introduction of new drugs such as FK 506, some of which are clearly synergistic with CsA, could ameliorate past problems with drug toxicity. With such improvements, and possibly even with more clever use of therapy that already is available, wider and more complex use of liver transplantation will be possible.
Related Concept Videos
Hepatic Drug Excretion: Enterohepatic Cycling
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Hepatic Drug Excretion: Influencing Factors
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

