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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

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Disease burden of congenital cytomegalovirus infection in Japan

Hirosato Aoki1, Taito Kitano2, Daisuke Kitagawa3

  • 1Department of Neonatology, Kanagawa Children's Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama, Kanagawa, 232-8555, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|September 11, 2020
PubMed

Insights

Congenital cytomegalovirus infection imposes a significant lifetime economic burden in Japan, estimated at 27.6 billion JPY in 2019. This highlights the need for national screening and early treatment strategies.

Area of Science:

  • Public Health
  • Health Economics
  • Infectious Diseases

Background:

  • Congenital cytomegalovirus (CMV) is a leading cause of congenital infections and newborn malformations in developed nations.
  • Despite global discussions on neonatal screening and treatment, data on the lifetime economic impact of congenital CMV is limited.
  • Understanding the economic burden is crucial for evaluating the cost-effectiveness of potential interventions.

Purpose of the Study:

  • To calculate the lifetime economic and health burdens associated with congenital cytomegalovirus infection in Japan.
  • To inform national strategies regarding neonatal screening and early treatment for congenital CMV.

Main Methods:

  • Economic and lifetime health burdens were estimated for the 2019 Japanese annual birth cohort.
  • Data utilized included demographic, epidemiologic, health value, and economic indicators.
  • The economic burden was categorized into medical and social costs, with sensitivity analysis performed.

Main Results:

  • The estimated total economic burden of congenital CMV infection in Japan for 2019 was 27.6 billion JPY.
  • Acute care medical costs represented a minor component of the overall economic burden.
  • Social costs significantly outweighed medical costs, indicating a substantial societal impact.

Conclusions:

  • The study quantifies the considerable economic burden of congenital CMV infection in Japan.
  • Findings underscore the disease's significance and provide valuable data for guiding national public health policies.
  • Results support the implementation of neonatal screening and early treatment programs to mitigate long-term costs.
Abstract

Keywords:
Cerebral palsyCytomegalovirusDisease burdenHearing lossQuality adjusted life years

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