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Updated: Dec 9, 2025
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Case of nivolumab-induced sclerosing cholangitis: lessons from long-term follow-up
Tess McClure1,2, Wanyuan Cui2,3, Khashayar Asadi4
1Gastroenterology, Austin Health, Heidelberg, Victoria, Australia tess.e.mcclure@gmail.com.
Abstract:
Nivolumab is an immune checkpoint inhibitor used to treat multiple solid-organ malignancies. While many of its immune-related adverse events are well established, nivolumab-induced sclerosing cholangitis remains poorly characterised, with no defined diagnostic criteria. Moreover, data regarding long-term outcomes are particularly lacking. We present a biopsy-proven case of nivolumab-induced sclerosing cholangitis, which uniquely captures 18 months of follow-up post-treatment. Our case highlights key features of intrahepatic subtype sclerosing cholangitis and suggests durable response to corticosteroid therapy.
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