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Updated: Dec 9, 2025
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Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
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Clinical and Neuroimaging Correlation in Patients with COVID-19
1From the Departments of Radiology (B.C.Y., K.B., M.L., B.P.A., M.D.L., W.A.M., Jr., S.P.R.) byoon@mgh.harvard.edu.
AJNR. American Journal of Neuroradiology
|September 11, 2020
Summary
Neuroimaging abnormalities like hemorrhage and infarction are common in severe COVID-19. These findings correlate with critical illness indicators such as intubation and acute kidney injury, highlighting neurological involvement in severe coronavirus disease 2019.
Area of Science:
- Neurology
- Radiology
- Infectious Diseases
Background:
- Coronavirus disease 2019 (COVID-19) presents with diverse neurological complications.
- Understanding the frequency and nature of acute intracranial abnormalities in COVID-19 patients is crucial.
Purpose of the Study:
- To determine the incidence of acute intracranial abnormalities on CT/MR imaging in COVID-19 patients.
- To investigate associations between neuroimaging findings and clinical severity markers.
Main Methods:
- Retrospective analysis of 150 COVID-19 patients undergoing brain CT/MR imaging.
- Evaluation for hemorrhage, infarction, and leukoencephalopathy.
- Correlation with clinical data including intubation and acute kidney injury.
Main Results:
- 17% of patients (26/150) showed abnormal neuroimaging findings.
- Hemorrhage (50%), infarction (42%), and leukoencephalopathy (27%) were observed.
- Abnormalities correlated significantly with ICU admission, intubation, and acute kidney injury.
Conclusions:
- COVID-19 patients exhibit a range of acute neuroimaging abnormalities.
- Severe COVID-19 is associated with a higher prevalence of these neuroimaging findings.
- Neuroimaging abnormalities may indicate more severe disease manifestations.
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