Related Experiment Video

Updated: Dec 9, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.8K

Palpitation was associated with clinical outcomes in patients with hypertrophic cardiomyopathy

Tingting Hu1, Tao Wang2, Xiwen Zhang3

  • 1Department of Cardiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Beijing West Road 6, Huai'an, 223001, China.

Scientific Reports
|September 11, 2020
PubMed

Insights

Palpitations, alongside chronic heart failure, predict adverse events in hypertrophic cardiomyopathy (HCM) patients. This common genetic heart condition

Area of Science:

  • Cardiology
  • Genetics
  • Clinical Outcomes Research

Background:

  • Hypertrophic cardiomyopathy (HCM) is a prevalent genetic heart disease with varied clinical manifestations.
  • Identifying novel predictors for clinical outcomes and survival is crucial for managing HCM patients.

Purpose of the Study:

  • To investigate palpitation as a potential predictor of major adverse cardiovascular and cerebrovascular events (MACCE) in HCM patients.
  • To assess the association between palpitation and specific adverse outcomes such as rehospitalization, cardiac death, and heart failure exacerbation.

Main Methods:

  • A study involving 206 HCM patients compared outcomes related to major adverse cardiovascular and cerebrovascular events.
  • Multivariable logistic analysis was employed to identify independent predictors of MACCE.
  • Kaplan-Meier analysis was used to evaluate prognosis in HCM patients without atrial fibrillation.

Main Results:

  • Palpitation, along with chronic heart failure (>1 year), independently predicted MACCE in HCM patients (OR 3.24, P=0.001).
  • Palpitation was significantly associated with increased rehospitalization (OR 3.86, P<0.001), cardiac death (OR 2.96, P=0.04), and heart failure exacerbation (OR 4.07, P<0.001).
  • Patients with palpitation did not exhibit significant differences in cardiac phenotype or function.

Conclusions:

  • Palpitation emerges as a novel and independent predictor of adverse clinical outcomes and overall survival in hypertrophic cardiomyopathy patients.
  • The presence of palpitation warrants close monitoring for potential adverse events, particularly in HCM patients without atrial fibrillation.

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.4K
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

557

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
236
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
280
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
706
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
181
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
312
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
517