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Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Related Experiment Video

Updated: Dec 9, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Spatial ultrasound modulation by digitally controlling microbubble arrays.

Zhichao Ma1, Kai Melde1, Athanasios G Athanassiadis1

  • 1Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, 70569, Stuttgart, Germany.

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|September 11, 2020
PubMed
Summary

Researchers developed a dynamic spatial ultrasound modulator (SUM) to control sound waves, enabling complex acoustic imaging and parallel particle assembly. This innovation offers a new tool for acoustic manipulation and imaging applications.

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Area of Science:

  • Acoustic physics
  • Wave manipulation
  • Microparticle dynamics

Background:

  • Acoustic waves are vital for imaging and manipulation through opaque materials.
  • High-fidelity wavefront shaping is crucial for advancing acoustic applications.
  • Existing methods lack dynamic control and scalability for sound wave modulation.

Purpose of the Study:

  • To introduce a dynamic spatial ultrasound modulator (SUM) analogous to optical spatial light modulators (SLMs).
  • To enable dynamic reshaping of acoustic waves into complex images.
  • To demonstrate scalable and dynamic control over acoustic holograms.

Main Methods:

  • Development of a spatial ultrasound modulator (SUM) using a microbubble pattern controlled by a CMOS chip.
  • Generation of binary amplitude acoustic holograms via digitally controlled microbubbles.
  • Sequential projection of dynamic acoustic images and parallel microparticle assembly.

Main Results:

  • The SUM dynamically reshapes incident plane waves into complex acoustic images.
  • A binary amplitude acoustic hologram is created using a microbubble transmission function.
  • The device successfully demonstrated dynamic parallel assembly of microparticles.

Conclusions:

  • The spatial ultrasound modulator (SUM) provides dynamic and scalable control over acoustic wavefronts.
  • This technology enables the creation of complex acoustic images and advanced particle manipulation.
  • The SUM represents a significant advancement for acoustic imaging and microparticle assembly applications.