CoQ10 suppression of oxidative stress and cell senescence increases bone mass in orchiectomized mice
Xuan Wu1, Shuo Liang2, Xingyu Zhu2
1Department of Orthopedics, Zhong Da Hospital, School of Medicine, Southeast University Nanjing 210009, Jiangsu, China.
Abstract:
Numerous studies support the detrimental effects of oxidative stress and cell senescence on skeletal homeostasis. Coenzyme Q10 (CoQ10) acts as a scavenger for oxidative stress and protects mitochondrial activity from oxidative damage. However, it is unclear whether CoQ10 has a protective effect on osteoporosis caused by orchiectomy. To investigate suppression effect of antioxidant CoQ10 on osteoporosis in orchiectomized (ORX) mice, ORX mice were supplemented with/without CoQ10, and were compared with each other and with sham-operated mice. Our results showed that CoQ10 could prevent ORX-induced bone loss by inhibiting oxidative stress and cell senescence, subsequently promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption. The results of this study not only reveal the mechanism of CoQ10 supplementation in anti-osteoporosis, but also provide experimental and theoretical basis for the clinical application of CoQ10 in the prevention of osteoporosis.
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:31Osteoclasts in Bone Remodeling
01:19The Effect of Aging on Tissues
01:25Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:31Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...