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Updated: Dec 9, 2025

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Long non coding RNA NRON inhibited breast cancer development through regulating miR-302b/SRSF2 axis

Qixin Mao1, Lianfang Li1, Chongjian Zhang1

  • 1Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University Zhengzhou, Henan, P. R. China.

American Journal of Translational Research
|September 11, 2020
PubMed
Abstract

Insights

Long noncoding RNA NRON (NRON) acts as a tumor suppressor in breast cancer by inhibiting proliferation and invasion. This study elucidates the NRON/miR-302b/SRSF2 axis, revealing NRON

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in cancer.
  • The function of lncRNA NRON in breast cancer pathogenesis is not well understood.
  • Previous studies implicated NRON in other cancer types, like hepatocellular carcinoma.

Purpose of the Study:

  • To investigate the role and mechanism of lncRNA NRON in breast cancer.
  • To determine if NRON acts as a tumor suppressor or oncogene in breast cancer.
  • To identify downstream targets and pathways regulated by NRON in breast cancer.

Main Methods:

  • Construction of NRON overexpression and knockdown vectors.
  • Assessment of breast cancer cell proliferation and invasion.
  • Dual-luciferase reporter assays to identify NRON binding targets.
  • Rescue experiments to confirm the NRON-SRSF2 interaction.

Main Results:

  • NRON expression was significantly downregulated in breast cancer tissues.
  • NRON overexpression suppressed breast cancer cell proliferation and invasion.
  • NRON knockdown promoted breast cancer development.
  • NRON negatively regulated miR-302b, which targets SRSF2.

Conclusions:

  • The lncRNA NRON/miR-302b/SRSF2 axis is a key player in breast cancer.
  • NRON functions as a tumor suppressor in breast cancer.
  • This study provides novel insights into the molecular mechanisms of breast cancer.
Keywords:
NRONbreast cancerlncRNAmiR-302b

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