Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study

Area of Science:

• Regenerative Medicine
• Wound Healing
• Traditional Chinese Medicine

Background:

• Perforator flaps are crucial in reconstructive surgery but are susceptible to ischemia and necrosis.
• Ischemia in perforator flaps leads to impaired blood supply, tissue edema, and cell death.
• Hydroxysafflor yellow A (HSYA), derived from safflower, exhibits pro-angiogenic, anti-apoptotic, and antioxidant properties.

Purpose of the Study:

• To investigate the efficacy of HSYA in improving perforator flap survival.
• To elucidate the underlying mechanisms by which HSYA promotes flap viability.

Main Methods:

• Animal models of perforator flaps were utilized.
• HSYA treatment was administered to assess its impact on flap survival.
• Histological and biochemical analyses were performed to evaluate angiogenesis, apoptosis, oxidative stress, and autophagy.

Main Results:

• HSYA significantly increased the survival area of perforator flaps.
• HSYA treatment led to enhanced blood supply and increased mean vascular density.
• HSYA effectively inhibited oxidative stress, apoptosis, and autophagy in the flap tissues.

Conclusions:

• HSYA demonstrates significant therapeutic potential for improving perforator flap survival.
• HSYA promotes flap viability by enhancing angiogenesis and mitigating ischemia-induced cellular damage.
• HSYA offers a promising therapeutic strategy for preventing necrosis in surgical flaps.