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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Pancreas01:19

Pancreas

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The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
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Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Steroid-responsive pancreatitides.

Mario Pelaez-Luna1, Andrea Soriano-Rios2, Ana C Lira-Treviño2

  • 1Research Division School of Medicine, Universidad Nacional Autonoma de México, Department of Gastroenterology, National Institute of Medical Sciences and Nutrition "Salvador Zubiran" Mexico City 14000, Mexico. mariopl@prodigy.net.mx.

World Journal of Clinical Cases
|September 11, 2020
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis and other conditions respond well to steroid therapy. This review proposes a new classification, "steroid-responsive pancreatitides," to better group these diverse pancreatic disorders.

Keywords:
Autoimmune pancreatitisCorticosteroidsIdiopathic duct centric chronic pancreatitisImmune checkpoint inhibitorsLymphoplasmacytic sclerosing pancreatitisVasculitis

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Area of Science:

  • Gastroenterology and Immunology
  • Pancreatic Diseases
  • Therapeutic Strategies

Background:

  • Autoimmune pancreatitis (AIP) is a significant pancreatic condition, with Type 1 AIP being extensively studied.
  • Current understanding acknowledges Type 1 and Type 2 AIP as distinct entities despite shared classification.
  • The efficacy of corticosteroid therapy is a key characteristic observed in AIP.

Purpose of the Study:

  • To review current knowledge on steroid-responsive pancreatic disorders.
  • To analyze the similarities and differences between various forms of pancreatitis that respond to steroids.
  • To propose a novel nomenclature for these conditions.

Main Methods:

  • Literature review of autoimmune pancreatitis and steroid-responsive pancreatic conditions.
  • Comparative analysis of pathophysiology, clinical presentation, and treatment outcomes.
  • Discussion of existing and proposed nomenclature for pancreatic diseases.

Main Results:

  • Corticosteroid therapy significantly impacts the clinical course of autoimmune pancreatitis.
  • Conditions beyond AIP, including pancreatitis secondary to vasculitis, connective tissue diseases, and cancer immunotherapies, also demonstrate responsiveness to steroids.
  • Existing nomenclature may not fully encompass the spectrum of steroid-responsive pancreatic conditions.

Conclusions:

  • A broader classification of "steroid-responsive pancreatitides" is proposed to encompass AIP and other steroid-sensitive pancreatic conditions.
  • This new nomenclature aims to improve clarity and awareness of these distinct yet related disorders.
  • Recognizing the shared therapeutic response can guide clinical management and future research.